Islet Cell Surface Antibodies in and Their Possible Influence on Tolerance Diabetes Glucose

OHGAWARA, H. and HIRATA, Y. Islet Cell Surface Antibodies in Diabetes and Their Possible Influence on Glucose Tolerance. Tohoku J. exp. Med., 1984, 142 (2), 211-216 The prevalence of islet cell surface antibodies (ICSA) in patients with insulin-dependent (IDD), noninsulin-dependent (NIDD) or newly-diagnosed diabetes mellitus was studied. The antibodies were present in 14 (27%) of 15 IDD patients below the age of 3O years, and in 11(12%) of 91 NIDD patients. Among 46 newly-diagnosed diabetic patients, (aged over 30 years), 14 (30%) were antibody-positive and had a fasting blood sugar exceeding 11 mmol glucose. The glucose tolerance after a standardized breakfast decreased in IDD or insulintreated patients with ICSA compared to patients without antibodies. C-peptide was also lower in patients with circulating ICSA (CPR/CBS during a standardized breakfast test 0.61±0.30 vs. 1.09±0.3 in IDD, 1.18±0.13 vs. 1.46±0.43 in the patients with insulin treatment). These results suggest that circulating ICSA be also present in some newly-diagnosed patients of over 30 years of age who require insulin treatment and who have an associated decreased glucose tolerance and C-peptide response. ICSA ; IDD ; NIDD ; C-peptide